Fibrosarcoma cells transduced with the IL-6 gene exhibited reduced tumorigenicity, increased immunogenicity, and decreased metastatic potential.

@article{Mullen1992FibrosarcomaCT,
  title={Fibrosarcoma cells transduced with the IL-6 gene exhibited reduced tumorigenicity, increased immunogenicity, and decreased metastatic potential.},
  author={Craig A. Mullen and M M Coale and Anna T. Levy and William G Stetler-Stevenson and Lance A. Liotta and Sabine Brandt and R. Michael Blaese},
  journal={Cancer research},
  year={1992},
  volume={52 21},
  pages={6020-4}
}
Murine fibrosarcoma cell lines transduced with retroviral vectors containing the murine interleukin 6 (IL-6) gene constitutively secreted IL-6. When injected s.c. into normal mice these IL-6-secreting tumors exhibited reduced tumorigenicity. This reduced tumorigenicity was not seen in nude or irradiated mice, implicating a T-cell-dependent, radiosensitive… CONTINUE READING