Fibronectin type III (FN3) modules of the neuronal cell adhesion molecule L1 interact directly with the fibroblast growth factor (FGF) receptor.

@article{Kulahin2008FibronectinTI,
  title={Fibronectin type III (FN3) modules of the neuronal cell adhesion molecule L1 interact directly with the fibroblast growth factor (FGF) receptor.},
  author={Nikolaj Kulahin and Shizhong Li and Anders Hinsby and Vladislav V. Kiselyov and Vladimir Berezin and Elisabeth Bock},
  journal={Molecular and cellular neurosciences},
  year={2008},
  volume={37 3},
  pages={528-36}
}
The neuronal cell adhesion molecule (CAM) L1 promotes axonal outgrowth, presumably through an interaction with the fibroblast growth factor receptor (FGFR). The present study demonstrates a direct interaction between L1 fibronectin type III (FN3) modules I-V and FGFR1 immunoglobulin (Ig) modules II and III by surface plasmon resonance analysis. Binding of L1 to FGFR1 was enhanced by adenosine 5'-triphosphate (ATP), adenylylmethylenediphosphonate (AMP-PCP), and guanosine-5'-triphosphate (GTP… CONTINUE READING