Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling.

@article{Telci2008FibronectintissueTM,
  title={Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling.},
  author={Dilek Telci and Zhihua Wang and Xiaoling Li and Elisabetta A M Verderio and Martin J Humphries and Manuela Baccarini and Huveyda Basaga and M. F. Griffin},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 30},
  pages={20937-47}
}
Heterotropic association of tissue transglutaminase (TG2) with extracellular matrix-associated fibronectin (FN) can restore the adhesion of fibroblasts when the integrin-mediated direct binding to FN is impaired using RGD-containing peptide. We demonstrate that the compensatory effect of the TG-FN complex in the presence of RGD-containing peptides is mediated by TG2 binding to the heparan sulfate chains of the syndecan-4 cell surface receptor. This binding mediates activation of protein kinase… CONTINUE READING

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