Fibronectin rigidity response through Fyn and p130Cas recruitment to the leading edge.

  title={Fibronectin rigidity response through Fyn and p130Cas recruitment to the leading edge.},
  author={Ana Kostic and Michael P Sheetz},
  journal={Molecular biology of the cell},
  volume={17 6},
Cell motility on extracellular matrices critically depends on matrix rigidity, which affects cell adhesion and formation of focal contacts. Receptor-like protein tyrosine phosphatase alpha (RPTPalpha) and the alphavbeta3 integrin form a rigidity-responsive complex at the leading edge. Here we show that the rigidity response through increased spreading and growth correlates with leading edge recruitment of Fyn, but not endogenous c-Src. Recruitment of Fyn requires the palmitoylation site near… CONTINUE READING


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