Fibronectin overexpression is associated with latent membrane protein 1 expression and has independent prognostic value for nasopharyngeal carcinoma

@article{Ma2013FibronectinOI,
  title={Fibronectin overexpression is associated with latent membrane protein 1 expression and has independent prognostic value for nasopharyngeal carcinoma},
  author={Li-Jung Ma and Sung-Wei Lee and Li-Ching Lin and Tzu-Ju Chen and I-Wei Chang and Han-Ping Hsu and Kwang-Yu Chang and H. Lisa Huang and C. Li},
  journal={Tumor Biology},
  year={2013},
  volume={35},
  pages={1703-1712}
}
Despite recent improvements in the diagnosis and treatment, the final outcomes in patients with nasopharyngeal carcinomas (NPC) still remain suboptimal. Through data mining from published transcriptomic database with further bioinformatic validation, fibronectin (FN1) was identified as a differentially upregulated gene in NPC tissues, which implicates the transition from epithelial to mesenchymal phenotype (EMT) and promotes metastasis. Given the roles of fibronectin in risk stratification and… CONTINUE READING