Fibronectin mediates Opc-dependent internalization of Neisseria meningitidis in human brain microvascular endothelial cells.

@article{Unkmeir2002FibronectinMO,
  title={Fibronectin mediates Opc-dependent internalization of Neisseria meningitidis in human brain microvascular endothelial cells.},
  author={Alexandra Unkmeir and Kirsten Latsch and Guido Dietrich and Eva Wintermeyer and Birgitta Schinke and Stefan Schwender and Kwang Sik Kim and Martin Eigenthaler and Matthias Frosch},
  journal={Molecular microbiology},
  year={2002},
  volume={46 4},
  pages={933-46}
}
A central step in the pathogenesis of bacterial meningitis caused by Neisseria meningitidis (the meningococcus) is the interaction of the bacteria with cells of the blood-brain barrier. In the present study, we analysed the invasive potential of two strains representing hypervirulent meningococcal lineages of the ET-5 and ET-37 complex in human brain-derived endothelial cells (HBEMCs). In contrast to previous observations made with epithelial cells and human umbilical vein-derived endothelial… CONTINUE READING