Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration.

@article{Wang2013FibronectinID,
  title={Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration.},
  author={Jinhu Wang and Ravi Karra and Amy L. Dickson and Kenneth D Poss},
  journal={Developmental biology},
  year={2013},
  volume={382 2},
  pages={427-35}
}
Unlike adult mammals, adult zebrafish vigorously regenerate lost heart muscle in response to injury. The epicardium, a mesothelial cell layer enveloping the myocardium, is activated to proliferate after cardiac injury and can contribute vascular support cells or provide mitogens to regenerating muscle. Here, we applied proteomics to identify secreted proteins that are associated with heart regeneration. We found that Fibronectin, a main component of the extracellular matrix, is induced and… CONTINUE READING

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