Fibronectin interaction with α4β1 integrin prevents apoptosis in B cell chronic lymphocytic leukemia: correlation with Bcl-2 and Bax

@article{Fuente1999FibronectinIW,
  title={Fibronectin interaction with α4β1 integrin prevents apoptosis in B cell chronic lymphocytic leukemia: correlation with Bcl-2 and Bax},
  author={M-T de la Fuente and Benito Casanova and Mercedes Garc{\'i}a-Gila and Ana C.R. da Silva and {\'A}ngeles Garc{\'i}a-Pardo},
  journal={Leukemia},
  year={1999},
  volume={13},
  pages={266-274}
}
B cell chronic lymphocytic leukemia (B-CLL) consists of the accumulation of malignant cells that apparently escape normal apoptotic regulation. We have studied the role of α4β1 integrin/fibronectin interaction in preventing apoptosis of these cells in vitro. B cells from 16 patients showed constant expression of α4β1 and little or no α5β1 B-CLL cells… CONTINUE READING