Fibronectin induces capacitation-associated events through the endocannabinoid system in bull sperm.

  title={Fibronectin induces capacitation-associated events through the endocannabinoid system in bull sperm.},
  author={Claudia Osycka-Salut and Eduardo Mart{\'i}nez-Le{\'o}n and Maria Gracia Gervasi and Luciana Castellano and Carlos Alberto Davio and Nicol{\'a}s Chiarante and Ana M Franchi and Mar{\'i}a Laura Ribeiro and Emilce Silvina D{\'i}az and Silvina Perez-Martinez},

Role of Integrins in Sperm Activation and Fertilization

This review discusses the existing view of the role of integrins during sperm migration through the female reproductive tract; oviductal reservoir formation; sperm maturation processes ensuing capacitation and the acrosome reaction, and their direct and indirect involvement in gamete membrane adhesion and fusion leading to fertilization.

Evaluation of sperm integrin α5β1 as a potential marker of fertility in humans

The evaluation of sperm integrin α5β1 immunolocalization could be a useful tool to select sperm with fertilizing ability from human semen samples before IVF procedures.

TRPV1 in male reproductive system: focus on sperm function

This paper is the first to review the expression and mechanism of TRPV1 in the male reproductive system from molecular and cellular perspectives, focusing on sperm function, including calcium homeostasis, crosstalk with endocannabinoid system, participation in cholesterol-related sperm maturation, and thermotaxis, hoping to capture the current situation of this rapidly developing field.

Partial Sperm beta1 Integrin Subunit Deletion Proves Its Involvement in Mouse Gamete Adhesion/Fusion

It is shown for the first time that the deletion, even partial, of the sperm Itgb1 gene makes the sperm unable to normally fertilize oocytes and demonstrates that sperm, but not oocyte, beta1 integrin subunit is involved in gamete adhesion/fusion.

Micrococcal nuclease sequencing of porcine sperm suggests a nucleosomal involvement on semen quality and early embryo development

A cross-species comparison of nucleosome-associated DNAs in sperm revealed positional conservation of the nucleosomes retention between human and pig, suggesting a clear relationship between nucleosomal positioning in sperm and sperm and embryo development.

Bull spermatozoa selected by thermotaxis exhibit high DNA integrity , speci � c head morphometry , and improve ICSI outcome

Sara Ruiz (  ) INIA: Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria Rosane Mazzarella INIA: Instituto Nacional de Investigacion y Tecnologia Agraria y

Sex Manipulation Technologies Progress in Livestock: A Review

This review described the brief history of sex manipulation, and the research progresses of common methods used in sex manipulation thus far, and can inform future studies on expanding the scope and use ofsex manipulation technologies in livestock.



Characterization of the endocannabinoid system in boar spermatozoa and implications for sperm capacitation and acrosome reaction

It is shown that sperm cells have a complete and efficient endocannabinoid system, and that activation of cannabinoid or vanilloid receptors controls, at different time-points, sperm functions required for fertilization.

Fibronectin modulates the endocannabinoid system through the cAMP/PKA pathway during human sperm capacitation

Findings indicate that Fn stimulates human sperm capacitation via the cAMP/PKA pathway through modulation of the endocannabinoid system.

Fibronectin stimulates human sperm capacitation through the cyclic AMP/protein kinase A pathway.

Fibronectin is a novel discovery that extends the current knowledge concerning normal and pathological sperm physiology as well as events that regulate the process of fertilization.

Anandamide Induces Sperm Release from Oviductal Epithelia through Nitric Oxide Pathway in Bovines

It is suggested that anandamide regulates the sperm release from oviductal epithelia probably by activating the nitric oxide pathway during sperm capacitation.

The endocannabinoid system in bull sperm and bovine oviductal epithelium: role of anandamide in sperm-oviduct interaction.

The findings indicate for the first time that the endocannabinoid system is present in bovine sperm and oviductal epithelium and that anandamide modulates the sperm-oviduct interaction, by inhibition of sperm binding and induction of sperm release from ovidUCTal epithelial cells, probably by activating CB1 receptors.

Sperm Release From the Oviductal Epithelium Depends on Ca2+ Influx Upon Activation of CB1 and TRPV1 by Anandamide

Findings indicate that anandamide, through CB1 and TRPV1 activation, is involved in sperm release from the oviductal reservoir, and suggest that an increase of sperm Ca2+ levels and the PLC activation might be involved in an andamide signaling pathway.

Anandamide Capacitates Bull Spermatozoa through CB1 and TRPV1 Activation

The results indicated that, URB597, a potent inhibitor of the FAAH, produced effects on bovine sperm capacitation similar to those elicited by exogenous AEA suggesting that this process is normally regulated by an endogenous tone.

Ca2+‐Regulating mechanisms that modulate bull sperm capacitation and acrosomal exocytosis as determined by chlortetracycline analysis

It is suggested that Ca2+ is required for functional changes in bull sperm, with aCa2+‐ATPase modulating intracellular Ca2 + during capacitation and calcium channels controlling the Ca2- influx required for acrosomal exocytosis.