Fibronectin gene polymorphisms are associated with the development of B-cell lymphoma in type II mixed cryoglobulinemia.

@article{Fabris2008FibronectinGP,
  title={Fibronectin gene polymorphisms are associated with the development of B-cell lymphoma in type II mixed cryoglobulinemia.},
  author={Martina Fabris and Luca Quartuccio and Sara Salvin and Gabriele Pozzato and Valli De Re and Cesare Mazzaro and Clodoveo Ferri and Chiara Baldini and Salvatore de Vita},
  journal={Annals of the rheumatic diseases},
  year={2008},
  volume={67 1},
  pages={80-3}
}
OBJECTIVE To analyse fibronectin (FN) gene polymorphisms in type II mixed cryoglobulinemic syndrome (MCsn), an immune-complex mediated systemic vasculitis linked to hepatitis C virus (HCV) infection and characterised by rheumatoid factor (RF) positive B-cell proliferation at high risk for the progression into non-Hodgkin's lymphoma (NHL). METHODS Samples from 74 patients with MCsn (type II serum cryoglobulins and clinical signs of vasculitis) were studied. In all, 58 (78.4%) patients were HCV… CONTINUE READING