Fibronectin fibrils regulate TGF-β1-induced Epithelial-Mesenchymal Transition.

@article{Griggs2017FibronectinFR,
  title={Fibronectin fibrils regulate TGF-β1-induced Epithelial-Mesenchymal Transition.},
  author={Lauren A Griggs and Nadiah T. Hassan and Roshni S. Malik and Brian Philip Griffin and Brittany A Martinez and Lynne W. Elmore and Christopher A. Lemmon},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2017},
  volume={60-61},
  pages={
          157-175
        }
}
Epithelial-Mesenchymal Transition (EMT) is a dynamic process through which epithelial cells transdifferentiate from an epithelial phenotype into a mesenchymal phenotype. Previous studies have demonstrated that both mechanical signaling and soluble growth factor signaling facilitate this process. One possible point of integration for mechanical and growth factor signaling is the extracellular matrix. Here we investigate the role of the extracellular matrix (ECM) protein fibronectin (FN) in this… CONTINUE READING
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