Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer.

@article{Bae2013FibronectinEI,
  title={Fibronectin expression in carcinoma cells correlates with tumor aggressiveness and poor clinical outcome in patients with invasive breast cancer.},
  author={Young Kyung Bae and Aeri C Kim and Min Kyoung Kim and Jung Eun Choi and Su Hwan Kang and Soo Jung Lee},
  journal={Human pathology},
  year={2013},
  volume={44 10},
  pages={2028-37}
}
Fibronectin (FN), a large heterodimeric glycoprotein, can be found in soluble form in plasma or in insoluble form as an extracellular matrix protein. Cellular FN is produced by various types of benign and malignant epithelial and mesenchymal cells and is widely distributed in malignant tumors. We evaluated FN expression in cancer cells (epithelial FN; E-FN) and intratumor stroma (stromal FN, S-FN) of 1596 invasive breast cancer samples using immunohistochemistry on tissue microarrays… CONTINUE READING