Fibronectin degradation; an in-vitro model of neutrophil mediated endothelial cell damage.

@article{Forsyth1990FibronectinDA,
  title={Fibronectin degradation; an in-vitro model of neutrophil mediated endothelial cell damage.},
  author={Kevin D Forsyth and Roland J. Levinsky},
  journal={The Journal of pathology},
  year={1990},
  volume={161 4},
  pages={313-9}
}
We have observed that fibronectin has a characteristic fibrillar morphology within the extracellular matrix surrounding endothelial cells. This morphology, which is easily recognizable by conventional immunoperoxidase techniques, is disrupted if neutrophils are induced to degranulate on endothelial monolayers. Loss of the fibrillar morphology (degraded fibronectin) is characterized by fragmentation and diffuse spreading of fibronectin over the surface of the endothelial cells. Loss of the… CONTINUE READING