Fibronectin-bound α5β1 integrins sense load and signal to reinforce adhesion in less than a second.

Abstract

Integrin-mediated mechanosensing of the extracellular environment allows cells to control adhesion and signalling. Whether cells sense and respond to force immediately upon ligand-binding is unknown. Here, we report that during adhesion initiation, fibroblasts respond to mechanical load by strengthening integrin-mediated adhesion to fibronectin (FN) in a… (More)
DOI: 10.1038/nmat5023

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6 Figures and Tables