Fibronectin-associated Fas ligand rapidly induces opposing and time-dependent effects on the activation and apoptosis of T cells.

@article{ZaninZhorov2003FibronectinassociatedFL,
  title={Fibronectin-associated Fas ligand rapidly induces opposing and time-dependent effects on the activation and apoptosis of T cells.},
  author={Alexandra Zanin-Zhorov and Rami Hershkoviz and Iris Hecht and Liora Cahalon and Ofer Lider},
  journal={Journal of immunology},
  year={2003},
  volume={171 11},
  pages={5882-9}
}
Recently, it has been shown that Fas ligand (FasL) interacts with the extracellular matrix (ECM) protein fibronectin (FN), and that the bound FasL retains its cytotoxic efficacy. Herein, we examined the ramifications of FasL-ECM protein interactions throughout a specific time period, in the absence or presence of additional activating molecules, assuming… CONTINUE READING