Fibronectin Matrix Regulates Activation of RHO and CDC42 GTPases and Cell Cycle Progression

@article{Bourdoulous1998FibronectinMR,
  title={Fibronectin Matrix Regulates Activation of RHO and CDC42 GTPases and Cell Cycle Progression },
  author={Sandrine Bourdoulous and Gertraud Orend and Deidre A Mackenna and Renata Pasqualini and Erkki Ruoslahti},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={143},
  pages={267 - 276}
}
Adherent cells assemble fibronectin into a fibrillar matrix on their apical surface. The fibril formation is initiated by fibronectin binding to the integrins alpha5 beta1 and alphav beta3, and is completed by a process that includes fibronectin self-assembly. We found that a 76- amino acid fragment of fibronectin (III1-C) that forms one of the self-assembly sites caused disassembly of preformed fibronectin matrix without affecting cell adhesion. Treating attached fibroblasts or endothelial… CONTINUE READING
75 Citations
55 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 75 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Similar Papers

Loading similar papers…