Fibromyalgia Patients are not only Hypersensitive to Painful Stimuli but also to Sound Stimuli.

  title={Fibromyalgia Patients are not only Hypersensitive to Painful Stimuli but also to Sound Stimuli.},
  author={Roland Staud and Melyssa Godfrey and Michael Edward Robinson},
  journal={The journal of pain},

Altered Pain in the Brainstem and Spinal Cord of Fibromyalgia Patients During the Anticipation and Experience of Experimental Pain

The results demonstrate significant differences in brainstem/spinal cord network connectivity between the FM and control groups which also correlated with individual differences in pain responses.

Long-lasting reflexive and nonreflexive pain responses in two mouse models of fibromyalgia-like condition

This is the first study showing that RIM6 and ASI mouse models show reflexive and nonreflexive responses up to 5–6 weeks, accompanied by either astro- or microgliosis in the spinal cord as pivotal physiopathology processes related to such condition development.

Advances in the management of fibromyalgia: what is the state of the art?

  • R. Staud
  • Psychology, Medicine
    Expert opinion on pharmacotherapy
  • 2022
This manuscript examines currently prescribed therapeutic approaches supported by empirical evidence as well as promising novel treatments for Fibromyalgia, finding cannabinoids and naltrexone appear promising.

Fibromyalgia and Associated Disorders: From Pain to Chronic Suffering, From Subjective Hypersensitivity to Hypersensitivity Syndrome

It is possible to define fibromyalgia as a cognitive disorder of cortical integration of chronic pain, with amplification of painful and sensory nociception, decrease in the threshold for the perception of pain, and persistence of a stimulus that maintains the process in chronicity.



Neurophysiologic evidence for a central sensitization in patients with fibromyalgia.

The results strongly point to a state of central hyperexcitability of the nociceptive system in patients with FM, and the NFR can be used to assess central allodynia in FM.

Fibromyalgia as a disorder of perceptual organization? An analysis of acoustic stimulus processing in patients with widespread pain

The results support the notion of a generalized disturbancy of perceptual thresholds in patients with fibromyalgia not restricted to the perception of pain, as a form of either pre-conscious or conscious acts to protect against disturbing stimulation.

Fibromyalgia: an afferent processing disorder leading to a complex pain generalized syndrome.

Although there is no known cure for fibromyalgia, multidisciplinary team efforts using combined treatment approaches, including patient education, aerobic exercise, cognitive behavioral therapy, and pharmacologic therapies might improve symptoms as well as function in patients with fibromy arthritis.