Fibromyalgia: from pathophysiology to therapy

@article{SchmidtWilcke2011FibromyalgiaFP,
  title={Fibromyalgia: from pathophysiology to therapy},
  author={Tobias Schmidt-Wilcke and Daniel J. Clauw},
  journal={Nature Reviews Rheumatology},
  year={2011},
  volume={7},
  pages={518-527}
}
Individuals with fibromyalgia generally experience chronic widespread pain, which can be accompanied by further symptoms including fatigue, sleep disturbances, cognitive dysfunction, anxiety and depressive episodes. As the recognition and diagnosis of fibromyalgia has improved, the availability of therapeutic options for patients has increased. Furthermore, research into the neurobiological mechanisms that contribute to the chronic pain and concomitant symptoms experienced by patients with… 
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164 Citations
Highly Influential Citations
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Background Citations
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Results Citations
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164 Citations

Fibromyalgia Syndrome in Need of Effective Treatments
TLDR
The management of FMS requires a multidimensional approach including patient education, behavioral therapy, exercise, and pain management, and new directions for research and treatment are proposed.
Neurobiology of fibromyalgia and chronic widespread pain
A framework for fibromyalgia management for primary care providers.
FIBROMYALGIA: PRESENT AND FUTURE! WHERE WE STAND
TLDR
Only three drugs, pregabalin, duloxetine, and milnacipran are currently FDAapproved for Fibromyalgia treatment, but many other agents have been tested over the years, with varying results.
Acupuncture and Trigger Point Injections for Fibromyalgia: East-West Medicine Case Report.
TLDR
A case report is presented of a patient with fibromyalgia who was successfully treated with an integrative approach that combined acupuncture with trigger point injections that provides improved clinical outcomes.
Neural therapy for fibromyalgia: Myth or improving quality of life?
TLDR
Evaluated the effectiveness of neural therapy on pain and functionality in patients with fibromyalgia to correct the underlying neuroendocrine dysfunction.
Do Fibromyalgia Flares Have a Neurobiological Substrate?
TLDR
The 2010 ACR preliminary diagnostic criteria for FM offer nonspecialists a new diagnostic approach that does not require tender point examination and counting, and provide a symptom severity scale and a recognition of the importance of cognitive and somatic symptoms in this disorder.
Mast Cells, Neuroinflammation and Pain in Fibromyalgia Syndrome
TLDR
It is hypothesized that thalamic mast cells contribute to inflammation and pain, by releasing neuro-sensitizing molecules that include histamine,IL-1β, IL-6 and TNF, as well as calcitonin-gene related peptide (CGRP), HK-1 and SP.
The relationship between fibromyalgia, stress and depression
TLDR
Emerging evidence indicates that fibromyalgia and depression are both syndromes, which affects the way in which each disorder should be considered, as indicated by a large body of conflicting literature.
Updated Treatment of Fibromyalgia Syndrome: A Review
Fibromyalgia is a debilitating condition that is frequently misdiagnosed. It affects 2% of the population, with middle-aged women having the highest frequency. Fibromyalgia affects more women than…
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References

SHOWING 1-10 OF 170 REFERENCES
Pharmacotherapy in fibromyalgia (FM)--implications for the underlying pathophysiology.
The fibromyalgia syndrome: musculoskeletal pathophysiology.
  • S. Geel
  • Medicine, Psychology
    Seminars in arthritis and rheumatism
  • 1994
Therapy Insight: fibromyalgia—a different type of pain needing a different type of treatment
TLDR
It is suggested that fibromyalgia and related syndromes require a multimodal management program that is different from the standard used to treat peripheral pain (i.e. acute or inflammatory pain), and neuroactive compounds that downregulate sensory processing are recommended.
The Significance, Assessment, and Management of Nonrestorative Sleep in Fibromyalgia Syndrome
TLDR
People with fibromyalgia syndrome experience unrefreshing sleep, aches, hypersensitivity, and cognitive and emotional difficulties and the generalized hypersensitivity of the body is considered to be affected by disturbances in central nervous system functions.
Chronic pain and fatigue syndromes: overlapping clinical and neuroendocrine features and potential pathogenic mechanisms.
TLDR
Various components of the central nervous system appear to be involved, including the hypothalamic pituitary axes, pain-processing pathways, and autonomic nervous system, which lead to corresponding changes in immune function, which are postulate are epiphenomena rather than the cause of the illnesses.
Treatment of fibromyalgia syndrome with antidepressants: a meta-analysis.
TLDR
Antidepressant medications are associated with improvements in pain, depression, fatigue, sleep disturbances, and health-related quality of life in patients with FMS.
Antidepressant treatment of fibromyalgia. A meta-analysis and review.
Fibromyalgia is a common musculoskeletal pain disorder associated with mood disorders. Antidepressants, particularly tricyclics, are commonly recommended treatments. Randomized, controlled trials of…
Psychological pain treatment in fibromyalgia syndrome: efficacy of operant behavioural and cognitive behavioural treatments
TLDR
It is suggested that both OBT and CBT are effective in treating patients with FMS with some differences in the outcome measures specifically targeted by the individual treatments compared with an unstructured discussion group.
The fibromyalgia syndrome.
TLDR
In this review, exciting new insights into the aetiology, pathogenesis, diagnosis and treatment of fibromyalgia will be reviewed.
Comparison of tenoxicam and bromazepan in the treatment of fibromyalgia: a randomized, double-blind, placebo-controlled trial
...
...