Fibromyalgia: from pathophysiology to therapy

  title={Fibromyalgia: from pathophysiology to therapy},
  author={Tobias Schmidt-Wilcke and Daniel J. Clauw},
  journal={Nature Reviews Rheumatology},
Individuals with fibromyalgia generally experience chronic widespread pain, which can be accompanied by further symptoms including fatigue, sleep disturbances, cognitive dysfunction, anxiety and depressive episodes. As the recognition and diagnosis of fibromyalgia has improved, the availability of therapeutic options for patients has increased. Furthermore, research into the neurobiological mechanisms that contribute to the chronic pain and concomitant symptoms experienced by patients with… 
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Therapy Insight: fibromyalgia—a different type of pain needing a different type of treatment
It is suggested that fibromyalgia and related syndromes require a multimodal management program that is different from the standard used to treat peripheral pain (i.e. acute or inflammatory pain), and neuroactive compounds that downregulate sensory processing are recommended.
The Significance, Assessment, and Management of Nonrestorative Sleep in Fibromyalgia Syndrome
People with fibromyalgia syndrome experience unrefreshing sleep, aches, hypersensitivity, and cognitive and emotional difficulties and the generalized hypersensitivity of the body is considered to be affected by disturbances in central nervous system functions.
Chronic pain and fatigue syndromes: overlapping clinical and neuroendocrine features and potential pathogenic mechanisms.
Various components of the central nervous system appear to be involved, including the hypothalamic pituitary axes, pain-processing pathways, and autonomic nervous system, which lead to corresponding changes in immune function, which are postulate are epiphenomena rather than the cause of the illnesses.
Treatment of fibromyalgia syndrome with antidepressants: a meta-analysis.
Antidepressant medications are associated with improvements in pain, depression, fatigue, sleep disturbances, and health-related quality of life in patients with FMS.
Antidepressant treatment of fibromyalgia. A meta-analysis and review.
Fibromyalgia is a common musculoskeletal pain disorder associated with mood disorders. Antidepressants, particularly tricyclics, are commonly recommended treatments. Randomized, controlled trials of
Psychological pain treatment in fibromyalgia syndrome: efficacy of operant behavioural and cognitive behavioural treatments
It is suggested that both OBT and CBT are effective in treating patients with FMS with some differences in the outcome measures specifically targeted by the individual treatments compared with an unstructured discussion group.
The fibromyalgia syndrome.
In this review, exciting new insights into the aetiology, pathogenesis, diagnosis and treatment of fibromyalgia will be reviewed.