Fibromyalgia: a clinical review.

  title={Fibromyalgia: a clinical review.},
  author={Daniel J. Clauw},
  volume={311 15},
  • D. Clauw
  • Published 16 April 2014
  • Medicine
  • JAMA
IMPORTANCE Fibromyalgia is present in as much as 2% to 8% of the population, is characterized by widespread pain, and is often accompanied by fatigue, memory problems, and sleep disturbances. OBJECTIVE To review the epidemiology, pathophysiology, diagnosis, and treatment of fibromyalgia. EVIDENCE REVIEW The medical literature on fibromyalgia was reviewed from 1955 to March 2014 via MEDLINE and the Cochrane Central Registry of Controlled Trials, with an emphasis on meta-analyses and… 

Fibromyalgia, a missed comorbidity in spondyloarthritis: prevalence and impact on assessment and treatment

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  • Medicine
    Current opinion in rheumatology
  • 2017
Disease activity measures with subjective elements are conflated in patients with fibromyalgia and do not reliably assess true inflammatory disease, a finding which has been observed in other diseases such as rheumatoid arthritis and lupus.

Antipsychotics for fibromyalgia in adults.

Assessment of the efficacy, tolerability and safety of antipsychotics in fibromyalgia in adults found quetiapine was statistically superior to placebo in reducing sleep problems and anxiety and the quality of evidence was very low.

Consensus evidence-based clinical practice recommendations for the management of fibromyalgia

These recommendations provide an updated consensus on both the non-pharmacological and the pharmacological treatments of fibromyalgia, and provide strategies to reach optimal treat-to-target outcomes in common clinical scenarios.

Fibromyalgia and Nutrition: An Updated Review

The results of this review underline the need to carry out clinical studies of higher quality and rigor, possibly RCTs, focused on the role of nutrition in the symptoms and/or severity of FM.

Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment

Different clinical aspects of fibromyalgia are outlined, including the burden, diagnosis and treatment of this condition, and various hypotheses of fibroitalgia etiopathogenesis are discussed.

Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update

Fibromyalgia is a syndrome characterized by chronic and widespread musculoskeletal pain, often accompanied by other symptoms, such as fatigue, intestinal disorders and alterations in sleep and mood, and several diagnostic approaches have been developed in recent years, including the analysis of genetic, epigenetic and serological biomarkers.

Managing fibromyalgia with complementary and alternative medical exercise: a systematic review and meta-analysis of clinical trials

Fibromyalgia is a chronic medical condition of unclear etiopathology that diminished patients’ quality of life; chronic pain is the main symptom, yet patients with fibromyalgia struggle also with

Mirtazapine for fibromyalgia in adults.

The evidence for all outcomes were judged to be low- or very low-quality because of poor study quality, indirectness, imprecision, risk of publication bias, and sometimes low numbers of events.

Patient with Fibromyalgia

Management of inpatients with fibromyalgia is outlined in a manner that includes both pharmacologic and non-pharmacologic interventions, perceived challenges in management, pain assessment tools, modalities to avoid, and a discharge plan for pain management.

Cannabinoids for fibromyalgia.

The primary outcomes in this review were participant-reported pain relief of 50% or greater, Patient Global Impression of Change (PGIC) much or very much improved, withdrawal due to adverse events (tolerability) and serious adverseEvents (safety).



2012 Canadian Guidelines for the diagnosis and management of fibromyalgia syndrome: executive summary.

The present recommendations incorporate the new clinical concepts of FM as a clinical construct without any defining physical abnormality or biological marker, characterized by fluctuating, diffuse body pain and the frequent symptoms of sleep disturbance, fatigue, mood and cognitive changes.

Antidepressant treatment of fibromyalgia. A meta-analysis and review.

Fibromyalgia is a common musculoskeletal pain disorder associated with mood disorders. Antidepressants, particularly tricyclics, are commonly recommended treatments. Randomized, controlled trials of

Efficacy of multicomponent treatment in fibromyalgia syndrome: a meta-analysis of randomized controlled clinical trials.

There is strong evidence that multicomponents treatment has beneficial short-term effects on the key symptoms of FMS and strategies to maintain the benefits of multicomponent treatment in the long term need to be developed.

Understanding fibromyalgia: lessons from the broader pain research community.

The Role of Antidepressants in the Management of Fibromyalgia Syndrome

A quantitative analysis of the efficacy and harms of antidepressants in the management of adult FMS patients, using Cohen’s categories, found the effect size on pain was small and the ones on sleep, fatigue, depression and HRQOL were not substantial.

Alternative medical interventions used in the treatment and management of myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia.

Alternative treatments, acupuncture and several types of meditative practice show the most promise for future scientific investigation, and magnesium, l-carnitine, and S-adenosylmethionine are nonpharmacological supplements with the most potential for further research.

Canadian Pain Society and Canadian Rheumatology Association Recommendations for Rational Care of Persons with Fibromyalgia. A Summary Report

These guidelines should provide the health community with reassurance for the global care of patients with FM with the aim of improving patient outcome by reducing symptoms and maintaining function.

Duloxetine and other antidepressants in the treatment of patients with fibromyalgia.

  • L. Arnold
  • Medicine, Psychology
    Pain medicine
  • 2007
Duloxetine has been shown to be an effective and safe treatment for many of the symptoms associated with fibromyalgia, particularly for women, and agents with dual effects on serotonin and norepinephrine appear to have more consistent benefits than selective serotonin antidepressants for the treatment of persistent pain associated with Fibromyalgia.

Fibromyalgia symptoms are reduced by low-dose naltrexone: a pilot study.

It is concluded that low-dose naltrexone may be an effective, highly tolerable, and inexpensive treatment for fibromyalgia.