Fibromyalgia: A Disorder of the Brain?

@article{Schweinhardt2008FibromyalgiaAD,
  title={Fibromyalgia: A Disorder of the Brain?},
  author={Petra Schweinhardt and Khara M Sauro and M. Catherine Bushnell},
  journal={The Neuroscientist},
  year={2008},
  volume={14},
  pages={415 - 421}
}
This article presents evidence that fibromyalgia patients have alterations in CNS anatomy, physiology, and chemistry that potentially contribute to the symptoms experienced by these patients. There is substantial psychophysical evidence that fibromyalgia patients perceive pain and other noxious stimuli differently than healthy individuals and that normal pain modulatory systems, such as diffuse noxious inhibitory control mechanisms, are compromised in fibromyalgia. Furthermore, functional brain… 
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References

SHOWING 1-10 OF 41 REFERENCES

Fibromyalgia patients show an abnormal dopamine response to pain

These findings provide the first direct evidence that fibromyalgia patients have an abnormal dopamine response to pain and suggests that the therapeutic effects of dopaminergic treatments for this intractable disorder should be explored.

Striatal grey matter increase in patients suffering from fibromyalgia – A voxel-based morphometry study

Treatment of fibromyalgia and its symptoms

  • R. Staud
  • Psychology, Medicine
    Expert opinion on pharmacotherapy
  • 2007
The main symptoms of fibromyalgia syndrome (FM) are pain, stiffness, subjective weakness and muscle fatigue. Pain in FM usually fluctuates, as well as being ‘deep’ and is always associated with local…

Generalized hypervigilance in fibromyalgia: evidence of perceptual amplification

Mechanisms of Disease: genetics of fibromyalgia

Research over the past two decades has demonstrated that genetic polymorphisms in the serotoninergic, dopaminergic and catecholaminergic systems of pain transmission and processing are involved in the etiology of fibromyalgia, but additional candidates continue to emerge.

Decreased Central μ-Opioid Receptor Availability in Fibromyalgia

It is demonstrated that FM patients display reduced MOR binding potential within several regions known to play a role in pain modulation, including the nucleus accumbens, the amygdala, and the dorsal cingulate, which indicates altered endogenous opioid analgesic activity in FM.

Chronic widespread pain and fibromyalgia: what we know, and what we need to know.

Possible deficiencies of pain modulation in fibromyalgia.

Pain modulation, produced by a concurrent tonic stimulus in healthy persons, was not seen in the fibromyalgia group, and it remains to be established whether the pain reduction found in the healthy subjects was the conventional DNIC effect, another effect (e.g., distraction), or a combination of both.

Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome

Retrosplenial cortical activation in the fibromyalgia syndrome

PET measures of regional cerebral blood flow in fibromyalgic patients and controls at rest found higher retroplenial rCBF in patients than controls, which agrees with the notion that fibromyalgia pain reflects secondary hyperalgesia.