Fibromyalgia: A Disorder of the Brain?
@article{Schweinhardt2008FibromyalgiaAD, title={Fibromyalgia: A Disorder of the Brain?}, author={Petra Schweinhardt and Khara M Sauro and M. Catherine Bushnell}, journal={The Neuroscientist}, year={2008}, volume={14}, pages={415 - 421} }
This article presents evidence that fibromyalgia patients have alterations in CNS anatomy, physiology, and chemistry that potentially contribute to the symptoms experienced by these patients. There is substantial psychophysical evidence that fibromyalgia patients perceive pain and other noxious stimuli differently than healthy individuals and that normal pain modulatory systems, such as diffuse noxious inhibitory control mechanisms, are compromised in fibromyalgia. Furthermore, functional brain…
126 Citations
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Current evidence supports the view that at least some fibromyalgia symptoms are associated with brain dysfunctions or alterations, giving the long-held “it is all in your head” view of the disorder a new meaning.
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Functional data of neural activation abnormalities parallel structural findings of gray matter atrophy, alterations of intrinsic connectivity networks, and variations in metabolites levels along multiple pathways enable the understanding of fibromyalgia pathophysiology, and favor the future establishment of more tailored treatments.
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The results indicate that abnormal processing of innocuous somatosensory stimulation may contribute to the pathophysiology and clinical symptom severity of FMS, and structural alterations associated with FMS are likely to occur only in the grey matter.
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Fibromyalgia may be more appropriately grouped with other functional pain disorders, certain subgroups of fibromyalgia patients with high level of psychological distress could be additionally or solely grouped with affective spectrum disorders.
Brain Function in Fibromyalgia: Altered Pain Processing and Cognitive Dysfunction
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These studies have highlighted both the important role of central pain-processing mechanisms and its evidently multifactorial status and both the great discordance between pain complaints or severity and their supposed peripheral causes.
Fibromyalgia syndrome.
- MedicinePain management
- 2011
The goal of this article is to review the current understanding of the etiology, pathophysiology and diagnosis of fibromyalgia syndrome as well as the evidence for current treatment strategies and to discuss the new preliminary diagnostic criteria for fibromyalg syndrome.
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Evidence for genetic and environmental factors that predispose, precipitate, and perpetuate fibromyalgia and depression are reviewed and laboratory findings on the role of depression are included to support the development of reactive depression.
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FMS, in its typical manifestation, is accompanied by a combination of additional symptoms such as sleep disturbance, fatigue, and anxiety, and by other clinical manifestations such as depression, gastrointestinal symptoms, and headache.
An Ayurveda Approach for the Management of Fibromyalgia (A Literary Review)
- Medicine
- 2013
Some studies have been performed evaluating the role of herbs or herbal medicine for efficacy on fibromyalgia (FM), and massage therapy have the best evidence for effectiveness with FM.
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