Fibrolamellar carcinoma of the liver: composition of the extracellular matrix and expression of cell-matrix and cell-cell adhesion molecules.

@article{Scoazec1996FibrolamellarCO,
  title={Fibrolamellar carcinoma of the liver: composition of the extracellular matrix and expression of cell-matrix and cell-cell adhesion molecules.},
  author={Jean Yves Scoazec and J. F. Fl{\'e}jou and Antonia D'Errico and Michelangelo Fiorentino and Alessandra Zamparelli and A. F. Bringuier and G{\'e}rard Feldmann and Walter Franco Grigioni},
  journal={Hepatology},
  year={1996},
  volume={24 5},
  pages={1128-36}
}
We have analyzed the composition of the tumor stroma and the expression of cell-matrix and cell-cell adhesion molecules in 11 cases of fibrolamellar carcinoma of the liver (FLC), in comparison with 34 cases of hepatocellular carcinoma and 8 cases of focal nodular hyperplasia. Fibrolamellar carcinoma was characterized by the presence of large amounts of tenascin in tumor stroma and by the scarce expression of basement membrane components at the contact of neoplastic clusters. Like normal… CONTINUE READING