Fibrogenesis in Crohn's Disease

  title={Fibrogenesis in Crohn's Disease},
  author={John Burke and Jurgen J W Mulsow and C O'keane and Neil G Docherty and Ronald W Watson and P. R. O'Connell},
  journal={The American Journal of Gastroenterology},
INTRODUCTION:Over one-third of patients with Crohn's disease (CD) will develop an intestinal stricture and the great majority of these will require at least one surgical procedure. While the pathogenesis of inflammation in CD has been extensively investigated, knowledge of stricture pathogenesis remains limited. The aim of this review is to discuss the current understanding of fibrogenesis in CD and to outline potential directions in research and therapeutics.METHODS:The electronic literature… CONTINUE READING
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