Fibrofatty changes in failed pediatric cardiac allografts.

  title={Fibrofatty changes in failed pediatric cardiac allografts.},
  author={Jeffrey H. Sacks and William T. Mahle and Carlos R. Abramowsky and Charlotte Katherine Steelman and Kirk R. Kanter and Robert N. Vincent and Alexandria M Berg and Bahig M. Shehata},
  journal={Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society},
  volume={14 3},
The pathogenesis of right ventricular fibrofatty changes can be broadly divided into genetic or acquired. The genetic cause is termed arrhythmogenic right ventricular dysplasia, an inherited cardiomyopathy characterized by fibrofatty replacement of the right ventricular myocardium, and represents an underdiagnosed cardiac entity leading to syncope, recurrent ventricular tachycardias, heart failure, and sudden death. Our study demonstrates that fibrofatty changes can also be seen in pediatric… CONTINUE READING