Fibrocytes: emerging effector cells in chronic inflammation

  title={Fibrocytes: emerging effector cells in chronic inflammation},
  author={Ronald A S Reilkoff and Richard Bucala and Erica L. Herzog},
  journal={Nature Reviews Immunology},
Fibrocytes are mesenchymal cells that arise from monocyte precursors. They are present in injured organs and have both the inflammatory features of macrophages and the tissue remodelling properties of fibroblasts. Chronic inflammatory stimuli mediate the differentiation, trafficking and accumulation of these cells in fibrosing conditions associated with autoimmunity, cardiovascular disease and asthma. This Opinion article discusses the immunological mediators controlling fibrocyte… CONTINUE READING
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