Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling.

  title={Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling.},
  author={Junko Nagano and Kenichiro Kitamura and Kristine M. Hujer and Christopher J. Ward and Richard J. Bram and Ulrich Hopfer and Kimio Tomita and Chunfa Huang and R. Tyler Miller},
  journal={Biochemical and biophysical research communications},
  volume={338 2},
The predicted structure of the autosomal recessive polycystic kidney disease protein, fibrocystin, suggests that it may function as a receptor, but its function remains unknown. To understand its function, we searched for proteins that interact with the intracellular C-terminus of fibrocystin using the yeast two-hybrid system. From the screening, we found calcium modulating cyclophilin ligand (CAML), a protein involved in Ca(2+) signaling. Immunofluorescent analysis showed that both proteins… CONTINUE READING