Fibroblasts regulate variable aggressiveness of syndromic keratocystic and non-syndromic odontogenic tumors.

@article{Hong2014FibroblastsRV,
  title={Fibroblasts regulate variable aggressiveness of syndromic keratocystic and non-syndromic odontogenic tumors.},
  author={Y-Y Hong and F-Y Yu and J-F Qu and Feng Chen and Tie-jun Li},
  journal={Journal of dental research},
  year={2014},
  volume={93 9},
  pages={904-10}
}
UNLABELLED Keratocystic odontogenic tumors (KCOTs) are jaw lesions that can be either sporadic or associated with nevoid basal cell carcinoma syndrome, which typically occurs as multiple, aggressive lesions that can lead to large areas of bone destruction and resorption and cause major impairment and even jaw fracture. To clarify the role of fibroblasts in the aggressivness of syndromic (S-) as compared with non-syndromic (NS-) KCOTs, we assessed fibroblasts derived from 16 S- and NS-KCOTs for… CONTINUE READING