Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation.

@article{Moodley2003FibroblastsIF,
  title={Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation.},
  author={Yuben Moodley and Amelia K Scaffidi and Neil L. A. Misso and Carmel Keerthisingam and Robin J McAnulty and Geoffrey John Laurent and Steven E Mutsaers and Phillip J. Thompson and Darryl A Knight},
  journal={The American journal of pathology},
  year={2003},
  volume={163 1},
  pages={345-54}
}
Interleukin (IL)-6 and IL-11 are elevated in a variety of lung conditions and may impact on repair mechanisms in chronic inflammatory disorders. However, the mechanisms by which these cytokines influence fibroblast proliferation in normal and disease states have not been previously addressed. We examined the effect of these cytokines on proliferation and cell-cycle kinetics of primary human lung fibroblasts obtained from normal patients and patients with idiopathic pulmonary fibrosis (IPF). IL… CONTINUE READING

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