Fibroblasts inhibit the production of interleukin-12p70 by murine dendritic cells.

@article{Berthier2003FibroblastsIT,
  title={Fibroblasts inhibit the production of interleukin-12p70 by murine dendritic cells.},
  author={Rolande Berthier and Alexandra Rizzitelli and Catherine Martinon-Ego and A M Laharie and V{\'e}ronique Collin and Serge Chesne and Patrice N Marche},
  journal={Immunology},
  year={2003},
  volume={108 3},
  pages={
          391-400
        }
}
Interleukin-12 p70 (IL-12p70) is a key cytokine produced by dendritic cells (DC) able to drive the development of T helper type 1 (Th1) lymphocytes. We showed that thymic and other fibroblasts strongly inhibit IL-12p70 production by splenic DC stimulated by lipopolysaccharide plus either anti-CD40 or interferon-gamma (IFN-gamma) and by purified splenic DC stimulated by Pansorbin plus IFN-gamma. This IL-12p70 inhibitory activity is secreted in the conditioned medium of primary fibroblasts and… CONTINUE READING