Fibroblasts in mechanically stressed collagen lattices assume a "synthetic" phenotype.

@article{Kessler2001FibroblastsIM,
  title={Fibroblasts in mechanically stressed collagen lattices assume a "synthetic" phenotype.},
  author={Daniela Kessler and Sandra Dethlefsen and Ilka Haase and Markus Plomann and Frank Hirche and Thomas Krieg and Beate Eckes},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 39},
  pages={36575-85}
}
Fibroblasts are subjected to changes of the mechanical force balance during physiological as well as pathological situations, such as wound healing, development of hypertrophic scars, and fibrogenesis. However, the molecular response and the changes in fibroblast gene expression upon mechanical stimulation remain poorly understood. As an in vitro model, human dermal fibroblasts were cultured within a three-dimensional network of fibrillar collagen either under high (stressed) or low tension… CONTINUE READING
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