Fibroblasts from chronic wounds show altered TGF-beta-signaling and decreased TGF-beta Type II receptor expression.

@article{Kim2003FibroblastsFC,
  title={Fibroblasts from chronic wounds show altered TGF-beta-signaling and decreased TGF-beta Type II receptor expression.},
  author={B Kim and Heung Tae Kim and Seok Hee Park and Ji-Sun Cha and Tatyana Yufit and Seong-Jin Kim and Vincent J Falanga},
  journal={Journal of cellular physiology},
  year={2003},
  volume={195 3},
  pages={331-6}
}
Chronic wounds are characterized by failure to heal in a defined time frame. However, the pathogenic steps leading from the etiological factors to failure to heal are unknown. Recently, increasing evidence suggests that resident cells in chronic wounds display a number of critical abnormalities, including senescence and unresponsiveness to the stimulatory action of transforming growth factor-beta1 (TGF-beta1). In this study, we have determined some of the mechanisms that might be responsible… CONTINUE READING

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