Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death.

@article{Haan2004FibroblastsDF,
  title={Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death.},
  author={Judy B de Haan and Cecile Bladier and Mehrnoush Lotfi-Miri and Juliet M Taylor and Paul Hutchinson and Peter J Crack and Paul J. Hertzog and Ismail Kola},
  journal={Free radical biology & medicine},
  year={2004},
  volume={36 1},
  pages={53-64}
}
The Free Radical Theory of Aging proposes that reactive oxygen species (ROS) contribute to the pathophysiology of aging. Our previous data highlight the importance of antioxidant enzymes, superoxide dismutase 1 (Sod1) and glutathione peroxidase 1 (Gpx1), in regulating this process. Previously, we demonstrated that a perturbation in the Sod1-to-Gpx1 ratio… CONTINUE READING