Fibroblasts as local immune modulators in ocular allergic disease.

@article{Fukuda2006FibroblastsAL,
  title={Fibroblasts as local immune modulators in ocular allergic disease.},
  author={Ken I. Fukuda and Naoki Kumagai and Youichiro Fujitsu and Teruo Nishida},
  journal={Allergology international : official journal of the Japanese Society of Allergology},
  year={2006},
  volume={55 2},
  pages={121-9}
}
Vernal keratoconjunctivitis (VKC), a severe form of ocular allergic disease, is characterized by the formation of giant papillae at the upper tarsal conjunctiva and corneal lesions that threaten vision. Recent evidence indicates that resident fibroblasts function as immune modulators in the pathogenesis of the chronic allergic inflammation associated with VKC. The T helper 2 (Th2) cell-derived cytokines interleukin (IL)-4 and IL-13 stimulate the migration and proliferation of conjunctival… CONTINUE READING
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