Fibroblasts Rendered Antifibrotic, Antiapoptotic, and Angiogenic by Priming With Cardiosphere-Derived Extracellular Membrane Vesicles.

@article{Tseliou2015FibroblastsRA,
  title={Fibroblasts Rendered Antifibrotic, Antiapoptotic, and Angiogenic by Priming With Cardiosphere-Derived Extracellular Membrane Vesicles.},
  author={E Tseliou and Joseph Fouad and Heidi J Reich and Leandro N Slipczuk and Geoffrey de Couto and Mark A. Aminzadeh and Ryan C Middleton and Jackelyn Valle and Liu Weixin and Eduardo Marb{\'a}n},
  journal={Journal of the American College of Cardiology},
  year={2015},
  volume={66 6},
  pages={599-611}
}
BACKGROUND Cardiosphere-derived cells mediate therapeutic regeneration in patients after myocardial infarction and are undergoing further clinical testing for cardiomyopathy. The beneficial effects of cardiosphere-derived cells are mediated by the secretion of exosomes and possibly other extracellular membrane vesicles (EMVs). OBJECTIVES This study sought to investigate the effect of cardiosphere-derived EMVs (CSp-EMVs) on fibroblasts in vitro and tested whether priming with CSp-EMVs could… CONTINUE READING