Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver.

@article{sterreicher2011FibroblastspecificP1,
  title={Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver.},
  author={Christoph H. {\"O}sterreicher and Melitta Penz-Oesterreicher and Sergei I. Grivennikov and Monica Guma and Ekaterina K. Koltsova and Christian Datz and R. S{\'a}sik and Gary Hardiman and Michael Karin and David Brenner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 1},
  pages={308-13}
}
Cirrhosis is the end result of chronic liver disease. Hepatic stellate cells (HSC) are believed to be the major source of collagen-producing myofibroblasts in cirrhotic livers. Portal fibroblasts, bone marrow-derived cells, and epithelial to mesenchymal transition (EMT) might also contribute to the myofibroblast population in damaged livers. Fibroblast-specific protein 1 (FSP1, also called S100A4) is considered a marker of fibroblasts in different organs undergoing tissue remodeling and is used… CONTINUE READING

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Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice

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