Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis.


TGF-β1 signaling is a critical driver of collagen accumulation and fibrotic disease but also a vital suppressor of inflammation and epithelial cell proliferation. The nature of this multifunctional cytokine has limited the development of global TGF-β1 signaling inhibitors as therapeutic agents. We conducted phenotypic screens for small molecules that… (More)
DOI: 10.1172/JCI94624


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@article{Wei2017FibroblastspecificIO, title={Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis.}, author={Ying Wei and Thomas J Kim and David H. Peng and Dana Duan and Don L. Gibbons and Mitsuo Yamauchi and Julia R Jackson and Claude Jourdan Le Saux and Cheresa Calhoun and Jay I. Peters and Rik Derynck and Bradley J. Backes and Harold A Chapman}, journal={The Journal of clinical investigation}, year={2017}, volume={127 10}, pages={3675-3688} }