Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice.

@article{Denton2003FibroblastspecificEO,
  title={Fibroblast-specific expression of a kinase-deficient type II transforming growth factor beta (TGFbeta) receptor leads to paradoxical activation of TGFbeta signaling pathways with fibrosis in transgenic mice.},
  author={Christopher P. Denton and Bing Qing Zheng and L. A. R. Evans and Xu Shi-wen and Voon Ong and Ivan B. Fisher and Konstantinos Lazaridis and David J. Abraham and Carol Mary Black and Benoit de Crombrugghe},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 27},
  pages={25109-19}
}
To better understand the role of disrupted transforming growth factor beta (TGFbeta) signaling in fibrosis, we have selectively expressed a kinase-deficient human type II TGFbeta receptor (TbetaRIIDeltak) in fibroblasts of transgenic mice, using a lineage-specific expression cassette subcloned from the pro-alpha2(I) collagen gene. Surprisingly, despite previous studies that characterized TbetaRIIDeltak as a dominant negative inhibitor of TGFbeta signaling, adult mice expressing this construct… CONTINUE READING
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