Fibroblast senescence in pressure ulcers.

@article{Berg1998FibroblastSI,
  title={Fibroblast senescence in pressure ulcers.},
  author={Jerry S Vande Berg and Ross Rudolph and C Hollan and Patricia L Haywood-Reid},
  journal={Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society},
  year={1998},
  volume={6 1},
  pages={38-49}
}
Pressure ulcers appear as localized chronic wounds in the middle of normal functioning skin. This study focuses on pressure ulcer fibroblasts cultured from the ulcer bed, ulcer margin, and normal, nonulcerated skin adjacent to the wound. From these areas we show that pressure ulcer fibroblasts become prematurely senescent. Verification of senescence was based on failure of cell populations to undergo a 0.5 population doubling after 1 week in culture, light microscopic appearance of late-passage… CONTINUE READING

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