Fibroblast growth-stimulating activity of S100A9 (MRP-14).

@article{Shibata2004FibroblastGA,
  title={Fibroblast growth-stimulating activity of S100A9 (MRP-14).},
  author={Futoshi Shibata and Katsuyoshi Miyama and Fumie Shinoda and Jun Mizumoto and Katsuhiko Takano and Hideo Nakagawa},
  journal={European journal of biochemistry},
  year={2004},
  volume={271 11},
  pages={2137-43}
}
Fibroblasts play a critical role in chronic inflammation and wound healing. In this study, a fibroblast growth-stimulating factor was purified from the exudate of carrageenan-induced inflammation in rats. The purified protein was a disulfide-linked homodimer. Amino acid sequence analysis of the peptides generated by cleavage with cyanogen bromide and proteinase V8 resulted in identification of the protein as S100A9. Recombinant S100A9 as well as its disulfide-linked homodimer stimulated the… CONTINUE READING

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