Fibroblast growth factors and their receptors in cancer.

  title={Fibroblast growth factors and their receptors in cancer.},
  author={J\orgen Wesche and Kaisa Haglund and Ellen Margrethe Haugsten},
  journal={The Biochemical journal},
  volume={437 2},
FGFs (fibroblast growth factors) and their receptors (FGFRs) play essential roles in tightly regulating cell proliferation, survival, migration and differentiation during development and adult life. Deregulation of FGFR signalling, on the other hand, has been associated with many developmental syndromes, and with human cancer. In cancer, FGFRs have been found to become overactivated by several mechanisms, including gene amplification, chromosomal translocation and mutations. FGFR alterations… CONTINUE READING
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