Fibroblast growth factors and their receptors in the central nervous system

  title={Fibroblast growth factors and their receptors in the central nervous system},
  author={B. Reuss and O. Bohlen und Halbach},
  journal={Cell and Tissue Research},
  • B. Reuss, O. Bohlen und Halbach
  • Published 2003
  • Biology, Medicine
  • Cell and Tissue Research
  • Fibroblast growth factors (FGFs) and their receptors constitute an elaborate signaling system that participates in many developmental and repair processes of virtually all mammalian tissues. Among the 23 FGF members, ten have been identified in the brain. Four FGF receptors (FGFRs), receptor tyrosine kinases, are known so far. Ligand binding of these receptors greatly depends on the presence of heparan sulfate proteoglycans, which act as low affinity FGFRs. Ligand binding specificity of FGFRs… CONTINUE READING
    Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.
    • 428
    • PDF


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