Fibroblast growth factors (FGFS) increase breast tumor growth rate, metastases, blood flow, and oxygenation without significant change in vascular density.

@article{Okunieff2003FibroblastGF,
  title={Fibroblast growth factors (FGFS) increase breast tumor growth rate, metastases, blood flow, and oxygenation without significant change in vascular density.},
  author={Paul G Okunieff and Bruce M. Fenton and Lurong Zhang and Francis G. Kern and Timothy S. Wu and J Robert Greg and I. Ding},
  journal={Advances in experimental medicine and biology},
  year={2003},
  volume={530},
  pages={593-601}
}
Breast tumors expressing no detectable FGFs (MCF-7) were compared with tumors transfected with FGF4 or FGF1 (FGF4/MCF-7 or FGF1/MCF-7), and with MDA-MB-435, which produce endogenous FGF2. Tumor blood flow was measured by 133Xe diffusion, oxygen distribution was measured by Eppendorf pO2 histography, and vascular density was measured by CD31 staining. Tumors that overexpress angiogenic factors grew at a rate far exceeding that of MCF-7. The FGF producing tumors also had much higher metastatic… CONTINUE READING

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