Fibroblast growth factor signaling in Caenorhabditis elegans.

  title={Fibroblast growth factor signaling in Caenorhabditis elegans.},
  author={Christina Z Borland and J L Schutzman and Michael J. Stern},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={23 12},
Growth factor receptor tyrosine kinases (RTKs), such as the fibroblast growth factor receptor (FGFR), play a major role in how cells communicate with their environment. FGFR signaling is crucial for normal development, and its misregulation in humans has been linked to developmental abnormalities and cancer. The precise molecular mechanisms by which FGFRs transduce extracellular signals to effect specific biologic responses is an area of intense research. Genetic analyses in model organisms… CONTINUE READING
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