Fibroblast growth factor signaling controlling bone formation: an update.

@article{Marie2012FibroblastGF,
  title={Fibroblast growth factor signaling controlling bone formation: an update.},
  author={Pierre Jacques Marie},
  journal={Gene},
  year={2012},
  volume={498 1},
  pages={1-4}
}
Fibroblast Growth Factors (FGFs) regulate prenatal and postnatal bone formation through activation of FGF receptors (FGFR) and downstream signaling events. During the last decade, major advances have been made in our understanding of the mechanisms by which FGF/FGFR signaling controls osteoprogenitor cell replication and osteoblast differentiation and function. The analysis of the phenotype induced by FGF invalidation and mutations in FGFR allowed to delineate key FGF signaling pathways that… CONTINUE READING