Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis.

@article{Ponimaskin2008FibroblastGF,
  title={Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis.},
  author={Evgeni G. Ponimaskin and Galina Dityateva and Mika O. Ruonala and Masaki Fukata and Yuko Fukata and Fritz Kobe and Fred Silvester Wouters and Markus Delling and David S Bredt and Melitta Schachner and Alexander Dityatev},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 36},
  pages={
          8897-907
        }
}
During development of the nervous system, short- and long-range signals cooperate to promote axonal growth, guidance, and target innervation. Particularly, a short-range signal transducer, the neural cell adhesion molecule (NCAM), stimulates neurite outgrowth via mechanisms that require posttranslational modification of NCAM and signaling via receptors to a long-range messenger, the fibroblast growth factor (FGF). In the present study we further characterized a mechanism which regulates the… CONTINUE READING

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