Fibroblast growth factor receptor 3 signaling regulates the onset of oligodendrocyte terminal differentiation.

@article{Oh2003FibroblastGF,
  title={Fibroblast growth factor receptor 3 signaling regulates the onset of oligodendrocyte terminal differentiation.},
  author={Luke Y S Oh and Adam Denninger and Jennifer Sue Colvin and Aditee Vyas and Shubha Tole and David M Ornitz and Rashmi Bansal},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 3},
  pages={883-94}
}
Fibroblast growth factor receptor (FGFR) signaling is essential for nervous system development. We have shown that, in the normal postnatal brain, the spatial and temporal expression pattern of FGFR3 parallels the appearance of differentiated oligodendrocytes and that in culture FGFR3 is expressed maximally at the critical stage in the lineage at which oligodendrocyte late progenitors (Pro-OLs) enter terminal differentiation. Therefore, FGFR3 expression is positioned ideally to have an impact… CONTINUE READING

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