Fibroblast growth factor receptor-3 is expressed in undifferentiated intestinal epithelial cells during murine crypt morphogenesis.

@article{Vidrich2004FibroblastGF,
  title={Fibroblast growth factor receptor-3 is expressed in undifferentiated intestinal epithelial cells during murine crypt morphogenesis.},
  author={Alda Vidrich and Jenny M Buzan and Chibuzo Ilo and Leigh Bradley and Kirstin Skaar and Steven M. Cohn},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2004},
  volume={230 1},
  pages={114-23}
}
Prior studies have demonstrated that fibroblast growth factor receptor-3 (FGFR-3) regulates proliferation of undifferentiated intestinal epithelial cells in vitro. However, the function(s) of FGFR-3-mediated signaling during intestinal development and epithelial differentiation in vivo remain unknown. The goal of this study was to define the temporal, regional, and cell-specific patterns of FGFR-3 expression and its ligands during normal intestinal ontogeny and epithelial regeneration. Both the… CONTINUE READING

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