Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.

Abstract

FGFR2 is a membrane-spanning tyrosine kinase that serves as a high affinity receptor for several members of the fibroblast growth factor (FGF) family. To explore functions of FGF/FGFR2 signals in development, we have mutated FGFR2 by deleting the entire immunoglobin-like domain III of the receptor. We showed that murine FGFR2 is essential for… (More)

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Cite this paper

@article{Xu1998FibroblastGF, title={Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction.}, author={Xiaochen Xu and Milton C. Weinstein and Chang Li and Michael C. Naski and R. I. Cohen and Dorothy Ornitz and Prof. L. -D. Leder and C. Deng}, journal={Development}, year={1998}, volume={125 4}, pages={753-65} }