Fibroblast growth factor receptor 2 (Fgfr2) plays an important role in eyelid and skin formation and patterning.

@article{Li2001FibroblastGF,
  title={Fibroblast growth factor receptor 2 (Fgfr2) plays an important role in eyelid and skin formation and patterning.},
  author={Chaoying Li and Hong Guo and Xing Zhou Xu and W Bailey Weinberg and Chu Xia Deng},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2001},
  volume={222 3},
  pages={471-83}
}
Initiating as protruding ridges above and below the optic vesicle, the eyelids of mice grow across the eye and temporarily fuse in fetal life. Mutations of a number of genes disrupt this developmental process and result in a birth defect, "open-eyelids at birth." Here we show that a critical event for eyelid induction occurs at embryonic day 11.5 (E11.5) when the single cell-layered ectoderm in the presumptive eyelid territory increases proliferation and undergoes morphologic transition to form… CONTINUE READING