Fibroblast growth factor mediates hypoxia-induced endothelin-- a receptor expression in lung artery smooth muscle cells.

@article{Li2003FibroblastGF,
  title={Fibroblast growth factor mediates hypoxia-induced endothelin-- a receptor expression in lung artery smooth muscle cells.},
  author={Peng Li and Suzanne Oparil and J Z Sun and John A. Thompson and Yiu-Fai Chen},
  journal={Journal of applied physiology},
  year={2003},
  volume={95 2},
  pages={643-51; discussion 863}
}
We have previously demonstrated that endothelin (ET)-1 and its subtype A receptor (ET-AR) expression are increased in lung under hypoxic conditions and that activation of ET-AR by ET-1 is a major mediator of hypoxia-induced pulmonary hypertension in the rat. The present study tested the hypothesis that the hypoxia-responsive tyrosine kinase receptor-activating growth factors fibroblast growth factor (FGF)-1, FGF-2, and platelet-derived growth factor (PDGF)-BB stimulate expression of the ET-AR… CONTINUE READING