Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells.

  title={Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells.},
  author={Marie P. Fogarty and Brian Andrew Emmenegger and Linda L. Grasfeder and Trudy G. Oliver and Robert J Wechsler-Reya},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 8},
The Sonic hedgehog (Shh) and FGF signaling pathways regulate growth and differentiation in many regions of the nervous system, but interactions between these pathways have not been studied extensively. Here, we examine the relationship between Shh and FGF signaling in granule cell precursors (GCPs), which are the most abundant neural progenitors in the cerebellum and the putative cell of origin for the childhood brain tumor medulloblastoma. In these cells, Shh induces a potent proliferative… CONTINUE READING
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